The postoperative neurological management of patients with deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson’s disease is a complex and dynamic process that involves optimizing the stimulation parameters and decreasing the anti-parkinsonian medication while assessing the interactions of both treatment modalities. Neurologists who manage patients undergoing DBS therapy must have expert knowledge of the electro-anatomy of the subthalamic area and be familiar with the medical treatment of motor and non-motor symptoms. In clinical practice, finding the optimal programming parameters can be a challenging and time-consuming process. We have developed a computerized system to facilitate one of the bottlenecks of DBS therapy: the IPG (Internal Pulse Generator) programming. This system consists of a deformable physiological atlas built on more than 300 intra-operative macro-stimulations acquired from 30 Parkinson’s patients and of a non-rigid registration algorithm used to map these data into an atlas.
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