Multi-Analyte detection handheld analyzer for point-of-care application with disposable biochips

摘要

In this work, we present the development of a handheld analyzer for actuation and sensing control of a disposable biochip for point-of-care monitoring of clinically relevant parameters. The disposable biochip has integrated on-chip air bursting detonators for fluid driving linked to a smart passive microfluidic system and an array of biosensors capable of simultaneously monitoring Oxygen, Glucose and Lactate concentrations in human blood. The handheld analyzer houses the SMT (surface mount technology) based electronics system for providing the driving signals to the air bursting detonators and to monitor the analyte signals from the biosensors. We have designed, tested and characterized the analyzer using the disposable biochips to test analytes from human blood. The analyzer developed in this work is ～ 5.25"×3.5"×1.5" and is currently the smallest unit capable of multi-parameter detection from human blood samples.