Exploring Antibacterial and Antiadhesive Activities of Titanium Surface Modified with Hydroxyapatite Sol-Gel Containing Silver

摘要

Circumambient tissues infection is a common complication of implanted percutaneous and permucosal devices (PDs). In order to counter the infection, the titanium abutment surface of PDs was modified to achieve antibacterial and antiadhesive activities. Titanium discs were immersed into hydroxyapatite (HA) sol containing different mass fraction silver and thermally treated to get modified discs. The modified discs become more smoother and get crystal HA coatings containing silver. Silver ion release test demonstrate the release rate is very slow and the coating is a reservoir of silver. The antibacterial and antiadhesive effects of modified discs on Staphylococcus aureus and Porphyromonas gingivalis were evaluated. Modified titanium discs with silver significantly inhibited the growth of these two bacteria compared with both the polished titanium discs control and modified titanium discs without silver. And titanium discs modified with more silver have higher antibacterial activity and less bacteria adhesion in this study. These findings indicate that titanium surface modified with the HA sol-gel containing silver could achieve antibacterial and antiadhesive activities, and the abutments of PDs are promising to be modified by this method.