Cytomagnetometric measurement of the energy of the intracellular movements

摘要

Magnetic particles were given to macrophage-like cultured cells J774A.1 to perform cytomagnetometry in which the magnetic field from the cells was measured and the mechanical parameters of the cytoplasm and the energy E{sub}r of the intracellular movement were estimated. The response of the cells to ATP-synthesis inhibitor MIA measured by cytomagnetometry was intriguing; the energy E{sub}r became larger contrary to our expectation. We have been searching for the reason for this phenomenon by the immunofluorescent microscopy and the use of other drugs and cell types. The results have yielded some clue to the question, which we discuss in the present paper.