We revisit the exact shortest unique substring (SUS) finding problem, and propose its approximate version where mismatches are allowed, due to its applications in subfields such as computational biology. We design a generic in-place framework that fits to solve both the exact and approximate k-mismatch SUS finding, using the minimum 2n memory words plus n bytes space, where n is the input string size. By using the in-place framework, we can find the exact and approximate k-mismatch SUS for every string position using a total of O(n) and O(n~2) time, respectively, regardless of the value of k. Our framework does not involve any compressed or succinct data structures and thus is practical and easy to implement.
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