Molecular design of new biomaterials for controlled release

摘要

The design of new biomaterials and carriers for protein delivery by molecular design has been the subject of a number of studies in recent years. Of particular interest is their development as hydrogels for protein delivery. In our recent work, we have shown that diffusion-controlled delivery of proteins from hydrogels containing poly(ethylene glycol) (PEG) can be controlled by the three-dimensional structure. Promising new studies indicate that some of these hydrogel carriers are mucoadhesive and can be used for protein delivery. We have also reported various forms of adhesive hydrogels based on poly(acrylic acid) (PAA) or poly(methacrylic acid) (PMAA) which exhibit inhibition of the degradation of proteins (including insulin and calcitonin) by proteolytic enzymes.