Surface engineering and surface analysis of a biodegradable polymer with biotinylated end-groups

摘要

In the design of advanced polymeric biomaterials there is a need to tailor the surface chemistry of the biomaterial to elicit beneficial interactions with cells and biomolecules. To facilitate the fabrication of complex biomaterial surfaces we have previously described the synthesis and application of a poly(lactic acid)-poly(ethylene glycol) bock copolymer (PLA-PEG) with the biotinylated PEG end-groups (final polymer termed PLA-PEG-biotin) (see Figure 1).