In vivo profile of basulin~(TM), a new long-acting insulin formulation with polyaminoacid nanoparticles

摘要

Medusa~circle R nanoparticles of amphiphilic block polyaminoacids are an original, stable and biocompatible controlled release system capable of encapsulating various types of proteins and drugs by a simple one-step process. In particular, Medusa~circle R spontaneously associates insulin in a non denaturing and reversible process at biological pH. This property can be successfully applied to the sustained delivery of insulin, which is so far an unachieved goal.