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Myocardial anisotropy in genesis of abnormal Q waves in hypertrophic cardiomyopathy: a simulation study

机译:肥厚性心肌病变异常Q波生成的心肌各向异性:仿真研究

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摘要

Computer simulation with a whole-heart model was conducted to study genesis of abnormal Q waves in hypertrophic cardiomyopathy (HCM). The anatomic feature of HCM was modeled based on clinical echocardiogram images. Possible changes in anisotropy as well as in other electrophysiologic properties in hypertrophic tissue were simulated based on pathologic findings. Simulated ECGs showing the main features of HCM were obtained by assuming isotropic fiber orientation in hypertrophic tissue and by changing other properties from normal values. This study suggests a possible mechanism to account for abnormal Q waves in HCM.
机译:进行了全心模型的计算机模拟,以研究肥厚性心肌病(HCM)的异常Q波的成因。基于临床超声心动图图像模拟HCM的解剖学特征。基于病理发现,模拟了各向异性的各向异性的可能变化以及肥厚组织中的其他电生理学性质。模拟ECG通过假设肥大组织中的各向同性纤维取向并通过从正常值改变其他性质来获得HCM的主要特征。本研究表明,可能的机制考虑了HCM中的异常Q波。

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