Adaptive glasses wavefront sensorless Full-Field OCT for high-resolution retinal imaging over a wide field-of-view

摘要

The highest three-dimensional (3D) resolution possible in in-vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics. However, this combination brings important limitations, such as small field-of-view and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. Here, we mitigate these limitations by combining our compact time-domain full-field OCT (FFOCT) with a multi-actuator adaptive lens positioned just in front of the eye, in a technique we call the adaptive-glasses wavefront sensorless approach. Through this approach, we demonstrate that ocular aberrations can be corrected, increasing the FFOCT signal-to-noise ratio and enabling imaging of different retinal layers with a 2μm × 2μm × 8μm resolution over a 5°× 5° field-of-view, without major anisoplanatism influence.