18.3 An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution

摘要

Magnetic nanoparticles (MNP) can generate localized thermal stress in response to an external ac magnetic field, offering unique opportunities for a wide range of biomedical applications. For example, hyperthermia cancer therapy, which raises the local temperature of tumors up to 43–45°C, can trigger apoptosis and disrupt cancer cells’ ability to repair DNA damage [1]. In neuroscience, temperature-sensitive ion channels can be thermally activated using MNP-induced heating, which allows for minimally invasive brain stimulation [2,3]. Compared to dielectric heating and ohmic heating, MNP-based magnetic heating offers superior specificity and minimal damage to the surrounding tissues since most biological systems are non-magnetic.