A Review on Molecular Dynamics Simulation for Biological Effects of Pulsed Electric Field

摘要

In recent years, the electric field in the application of biological research has become a hot spot, However, the mechanism still lags behind the experimental study. Molecular dynamics simulation could not only get the atomic trajectory, but also get a variety of observation like to do the same experiment. Therefore we could choose molecular dynamics simulation to study the mechanism. This article discusses the basic principles of the molecular dynamics simulation; Comprehensive analysis research status and recent applications of Molecular dynamics simulation in electric field biological effect at home and abroad. In particular, we have a detailed description and analysis of the biological effects of pulsed electric field of molecular dynamics simulation results, such as nanopore formation at membranes in response to a high-intensity (~0.5Vm), nanosecond electric pulse. And On this basis, the development trends and application prospects of molecular dynamics simulation on pulsed electric field in the biological effects is put forward.