A crosstalk-based linear filter in biochemical signal transduction pathways for the internet of bio-things

摘要

Novel emerging tools are allowing the manipulation and control of biological cells and their functions, e.g., sensing, actuation, and communication through biochemical stimuli. These tools have the potential to enable the implementation of manmade networks of biological computing devices, i.e., Internet of Bio-things. In this work, signal transduction pathways, i.e., cells' chemical reactions that process biochemical signals, are proposed for the design of analog linear filters to be utilized as components in the Internet of Bio-things. These filters, which exploit the crosstalk of signal transduction pathways to achieve the desired response, are here modeled and analyzed. The relations between filter properties and biochemical parameters are presented with the goal of designing a notch filter. A preliminary numerical example is also given as proof-of-concept.