Core/Shell Iron Oxide@Gold Nanoparticles for dual-modal CT/MRI imaging

摘要

Multimodal imaging, integrating different imaging modalities, is emerging as a promising strategy for improving bothpreclinical and clinical imaging. Computed tomography (CT) and magnetic resonance imaging (MRI) are among thewidely clinically-used imaging techniques. These imaging modalities are used for disease diagnosis and screening, eachproviding different and complementary information about the patient and the disease state. Nanoparticles are consideredpromising contrast agents for in vivo imaging applications, providing improved imaging and targeting capabilitiescompared to the commonly used contrast compounds. In this project, we present the development of a novel hybridnanostructure, comprising of iron oxide core and gold shell nanoparticle for dual model CT and MRI imaging. The hybridstructures presented herein have potential to serve as a unique platform for precision imaging.