Simulation and Experimental Results of a Microuidic Dipole Designed for Brain Experiments

摘要

This paper describes a proof of concept of a microuidic dipole to sample cerebral uid. It consists of a portablemicrouidic probe which injects a buffer in one inlet and draws it from the other one after passing through acontact zone with the external liquid. Finite elements method modelling (FEM) shows a very stable liquid owacross the complete probing area. Furthermore, we determined that a design generating turbulence is likely tobe more useful to capture brain molecules. Molecules displacement due to diffusion phenomena takes about 25ms to diffuse over a 1 mm probe gap. Finally, our experiment showed that, to obtain a stable ow withoutturbulence the maximum inlet and outlet pressure is 0.05 mPa for the two tested configuration of dipole.