Toward artifact-free reconstruction of photoacoustic computed tomography images

摘要

As an emerging optical imaging modality, photoacoustic imaging provides optical absorption contrastsand ultrasonic high resolution. Artifacts appearing in photoacoustic computed tomography (PACT)always deteriorate image quality and resolution, and result in confusion of biological information. Onthe basis of different causing reasons, they are roughly classified as split artifacts and streak artifacts.Here we present an innovative Feature-Coupling (FC) method to weaken split artifacts with jointreconstruction of speed of sound and a new reconstruction algorithm, termed Contamination-TracingBack-Projection (CTBP), is proposed for the mitigation of streak artifacts. The utility, effectiveness androbustness of our methods were demonstrated using numerical, phantom, and in vivo experiments.