Cellular mechanical properties are an important indicator for assessing and analyzing the functions of cells. However, thestructure and compositions of the cell are complex. In order to analyze the effects of different components on themechanical properties of cells, a multi-structured 3D model of cancer cells considering the cytoskeleton, cytoplasm,nucleus and cell membrane was established by finite element method. And the tensegrity structure-finding algorithm wasused to analyze the cytoskeletal distribution and the pre-stress of each component. First, the model was verified bycomparing numerical results with force-indentation curve obtained by atomic force microscopy in Ho-8910 cells. Then,the elasticity modulus of cell were obtained via applying a load to the established model.Computational simulationshowed that cytoskeleton are the major component targeted in resisting compression.In addition, this model can provideuseful guidance for the measurement and analysis of single cell through atomic force microscopy.
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