UV-LED device effectively increases serum levels of 25(OH)D3 in osteoporosis rats

摘要

Osteoporosis is a bone disease associated with aging. As the population ages, osteoporosis has become a significantpublic health problem that threaten life quality of most countries in the world. Adequate vitamin D is able to improveintestinal calcium absorption, promote bone mineralization, maintain muscle strength, enhance balancing ability, andreduce fall risks, whichplays a vital role in bone metabolism. Moreover, vitamin D is mainly produced by ultraviolet(UV) light. The serum levels of 25(OH)D3 is the tools for estimating of the osteoporosis.It is known that vitamin Ddeficiency is ubiquitous in the elderly population, hence, we adopted UV light-emitting diode (UV-LED) instruments togenerate narrow-range wavelengths of UV and determined its capability for producing vitamin D. The osteoporosis SDrats are our research subjects.The study was to investigate the effects of UV-LEDs of different power densities on vitamin D production. Thereare 4 groups：0.1, 0.2, 0.4, 0.8mW/cm~2 and the rats (n = 6 per group) were irradiated with different power densitiestwice a week for a total of 8 weeks. The results showed that serum 25(OH)D3 levels rapidly increased in all irradiatedgroups compared with those in the control group (P < 0.001 in all groups), and 25(OH)D3 level of the rats in groups ofboth 0.4 and 0.8 m W/cm~2 were able to return to the initial level at the fourth week after irradiation, besides, the groupof 0.4 mW/ W/cm~2 can achieve and maintain the highest25(OH)D3 level and so as the group of 0.8 m W/cm~2 as thecontinuing irradiation. We demonstrate that the proper irradiation density of UV-LED irradiation can increase theproduction of vitamin D in rats and does not adversely affect the skin of rats.