Among different techniques based on x-ray nanoimaging, ptychography has become a popular tool to study specimensat nanometer-scale resolution without the need of using high-resolution optics that requires very stringentmanufacturing processes. This high-resolution imaging method is compatible with other imaging modalitiesacquired in scanning microscopy. At the Advance Photon Source (APS), we have developed two uorescencemicroscopes for simultaneous ptychography and uorescence imaging which together provide a powerful techniqueto study samples in biology, environmental science, and materials science. Combined with different tiltedsample projections, such correlative methods can yield high-resolution 3D structural and chemical images. Morerecent work has been focused on the development of a fast ptychography instrument called the Velociprobewhich is built to take advantage of the over 100 times higher coherent ux provided by the coming APS upgradesource. The Velociprobe uses high-bandwidth accurate interferometry and advanced motion controls with fastcontinuous scanning schemes which are optimized for large-scale samples and 3D high-resolution imaging. Thisinstrument has been demonstrated to obtain sub-10 nm resolution with different high-photon-efficient scanningschemes using fast data acquisition rate up to 3 kHz (currently limited by detector's full continuous frame rate).A ptychographic imaging rate of 100 μm~2/second with a sub-20 nm spatial resolution was shown in this paper.
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