Predicting circRNA-disease associations using deep generative adversarial network based on multi-source fusion information

摘要

Circular RNA (circRNA) is a kind of novel discovered non-coding RNA molecule with a closed loop structure, which plays a critical regulatory role in human diseases. Identifying the association between circRNAs and diseases has important potential value for the diagnosis and treatment of complex human diseases. Although biological experiments can more accurately identify the association between circRNAs and diseases, they are usually blind and limited by small scale and high cost. Therefore, there is an urgent need for efficient and feasible computational methods to predict the potential circRNA-disease associations on a large scale, so as to provide the most promising candidate for biological experiments. In this paper, we propose a novel computational method based on the deep Generative Adversarial Network (GAN) algorithm combined with the multi-source similarity information to predict the circRNA-disease associations. Firstly, we fuse the multi-source information of disease semantic similarity, disease and circRNA Gaussian interaction profile kernel similarity, and then use GAN to extract the hidden features of fusion information objectively and effectively in the way of confrontation learning, and finally send them to Logistic Model Tree (LMT) classifier for accurate prediction. The 5-fold cross-validation experiment of the proposed model achieved 89.2% accuracy with 89.4% precision at the AUC of 90.6% on the CIRCR2Disease dataset. Compared with the state-of-the-art SVM classifier and other feature extraction methods, the proposed model shows strong competitiveness. In addition, the predicted results of this model are supported by the biological experiments, and 9 of the top 15 circRNA-disease associations with the highest scores were confirmed by recently published literature. These promising results indicate that the proposed model is an effective tool for predicting circRNA-disease associations and can provide reliable candidates for biological experiments.