The Use of Fuzzy PROMETHEE Technique in Antiretroviral Combination Decision in Pediatric HIV Treatments

摘要

In this study, we analyzed the best treatment options in HIV pediatric cases among many antiretroviral drug combinations and each combination has different properties. Such many combinations can cause confusion for physicians practice. For this aim, we proposed fuzzy PROMETHEE technique, a multi-criteria decision-making technique based on the mutual comparison of the options. The most common antiretroviral drug combinations used in the pediatric HIV treatments (for the infants and for the children aged less than 3 years) were evaluated and compared corresponding to their parameters by PROMETHEE technique. We used the linguistic fuzzy scale for the importance of the weight of the selected parameters according to experts opinion. Integrase inhibitors based drug combinations (RAL; raltegravir + 3TC/ZDV; lamivudin/zidovudin) was found as best preferred regimes.