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A fast MEMS scanning Photoacoustic Microscopy system and its application in glioma study

机译:快速MEMS扫描光声显微镜系统及其在神经胶质瘤研究中的应用

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We present a water-proof Microelectromechanical systems (MEMS) based scanning optical resolution Photoacoustic Microscopy (OR-PAM) system and its application in glioma tumor mouse model study. The presented OR-PAM system has high optical resolution (~3 μm) and high scanning speed (up to 50 kHz A-scan rate), which is ideal for cerebral vascular imaging. In this study, the mice with glioma tumor are treated with vascular disrupting agent (VDA). OR-PAM system is utilized to image the cerebral with the whole skull intact before and after the injection of VDA. By image registration, the response of every single blood vessel can be traced. This will provide us deeper understanding of the drug effect.
机译:我们提出了一种基于防水微机电系统(MEMS)的扫描光学分辨率光声显微镜(OR-PAM)系统及其在神经胶质瘤肿瘤小鼠模型研究中的应用。提出的OR-PAM系统具有较高的光学分辨率(〜3μm)和较高的扫描速度(高达50 kHz A扫描速率),非常适合脑血管成像。在这项研究中,患有神经胶质瘤的小鼠用血管分裂剂(VDA)治疗。在注射VDA之前和之后,使用OR-PAM系统对整个颅骨完整的大脑进行成像。通过图像配准,可以追踪每个血管的反应。这将使我们对药物作用有更深的了解。

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