The performance of multi-bay flat slab substructures subjected to the loss of an interior column scenario is investigated experimentally. The influence of multi-column missing on the performance of flat slab substructures against progressive collapse is quantified. The test results including the dynamic load redistribution response, crack pattern, and displacement distribution response. The test results indicated that compressive membrane action could increase the dynamic load resistance of flat slab substructures efficiently. However, when both interior and exterior columns are lost, much larger dynamic response is achieved due to less compressive membrane action is able to develop.
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