Encapsulated organoids organ-on-a-chip platform for cancer modeling

摘要

This review highlights our major developments in the fields of organoids and organ-on-chip to address issues in fundamental and biomedical research by modeling development and cancer. We illustrate how contemporary miniaturized technologies (microfluidics, 3D scaffolding, 3D imaging) combined with RNAi-based organoids HTS (High-Throughput Screening), would help forming and analyzing consistent, efficient and reproducible organoids. Moreover, we illustrate the potential of engineered organ-on-chip devices for creating novel human organ and disease models, with particular focus on “prostate-on-a-chip”.