Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake

摘要

The abnormal vasculature of tumor and the resulting abnormal microenvironment is a major barrier to optimal chemotherapeutic drug delivery. It is well known that ultrasound (US) can increase the permeability of the tumor vessel walls and enhance the accumulation of anticancer drugs. Reconstituted high density lipoproteins (rHDL) nanoparticles (NPs) allow selective delivery of anticancer agents to tumor cells via their overexpressed SR-B1 receptor. The goal of this study is to investigate the potential of noninvasive US therapy to further improve delivery and tumor uptake of rHDL NPs preloaded with an infrared dye (IR780), which is devoted to the establishment of a surrogate chemotherapeutic model with optical localization.