Computational study of ATP gated Potassium ion channel in urinary bladder over activity

摘要

Enhanced spontaneous electrical activity in detrusor smooth muscle cell is a major cause of over active bladder. ATP sensitive Potassium channel, which may play a crucial part in modulating resting membrane potential of detrusor smooth muscle cell and hence in bladder over activity. The main objective of our study is to construct a computational model of ATP sensitive Potassium channel in DSM cell with sufficient biophysical details to investigate its' modulating role in electrical excitability. The model was based on documented electrophysiological data in published experimental studies. We have validated our simulated ATP sensitive Potassium ion channel current by comparing with experimental recordings and it showed positive agreements in numerous parameters. At the present time, our computational model provides an elementary tool to analyze the physiological role of ATP sensitive Potassium ionic current in detrusor smooth muscle electrical activity underlying the contractions in DSM cells that successively will shed light in genesis of bladder overactivity.