Analysis of superparamagnetic scaffolds: For bone tissue engineering in static magnetic and dynamic fields

摘要

Bone tissue engineering has obtained valuable results using biophysical stimulation through magnetic fields to enhance integration of prosthetic implants. Recently a new class of therapeutic scaffolds has been developed in order to activate remotely, in non-invasive way, using magnetic fields. In our work we analyzed the ability of these scaffolds to attract magnetic bioagents towards them, thanks to the magnetic field gradients due to the non-linear response of the prosthetic implant. The possibility of influence osteogenic and/or angiogenic cells is taken into account, and a simple chemotaxis model indirectly driven by magnetic field is proposed.