Real-time imaging, targeting, and ablation of ex-vivo tissue using a handheld histotripsy transducer and coregistered 64-element high-frequency endoscopic phased array

摘要

In this work, we have developed a small, handheld histotripsy transducer where the ablation focus is imaged in real-time using a co-registered 45 MHz 64-element phased array endoscope. The construction of a 2 cm diameter, 40% volume fraction, strongly curved, PZT5A composite transducer capable of generating cavitation within tissue is outlined. The co-registered imaging and ablation tool was able to ablate a 1 mm x 0.5 mm × 0.5 mm volume below the surface of a chinchilla brain using a single 5 second, 1 kHz PRF, 10 cycle burst, without damage to the surface leading to the ablation site. Total electrical power draw during treatment was less than 4 W.