A STUDY ON THE MECHANICAL PROPERTIES OF ACELLULAR DERMAL MATRICES AND THEIR INTERFACE PROPERTIES AFTER IMPLANTATION IN AN ACUTE ABDOMINAL WALL DEFECT IN A PRIMATE

摘要

Within Regenerative Medicine, non-cell-based approaches such as biologically-derived materials have been commercially successful and represent an important proportion of medically-used biomaterials. Several acellular matrices are commercially available, to be used as a reinforcement of soft tissue where weakness exists. The goal of this study was to determine whether out-of-package mechanical properties of an acellular tissue matrix was predictive of its in vivo interface strength and whether the in vivo interface strength was associated with a particular histological response. We chose to test three porcine dermis-derived acellular matrices and one bovine pericardium derived matrix.