The Analysis of the Inhibition Effect of Cholic Acid Derivatives on the Proliferation of Breast Cancer Cells

摘要

Cancer is one of the major causes of death worldwide. Many clinical evidences showed that the incidence of colon cancer increased after the chole-cystectomy, suggesting that bile acid and its derivatives might play roles in the process of tumorigenesis and its prevention. Bile acid derivative is a kind of good candidates for prodrug design, but there are still few reports of its development for anticancer drugs either domestically or internationally. In the present study, IC50 of 9 bile acid derivatives against MCF-7 human breast cancer cells was detected by MTT assay, and the safety of several bile acid derivatives with high anticancer effect were further analyzed in human umbilical vein endothelial cells. The results showed that among 9 bile acid derivatives, cholic acid n-buthyl ester had lower IC50 against cancer cells, but it did not have cytotoxicity to normal cell at low concentration, indicating that they would be a good candidate for the development of novel anticancer agents.