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Paired Neural Network with Negatively Correlated Features for Cancer Classification in DNA Gene Expression Profiles

机译:对DNA基因表达谱中癌症分类的癌症分类具有负相关性的神经网络

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While several conventional techniques for diagnosis of cancer in clinical practice can be often incomplete or misleading, molecular level diagnostics with gene expression profiles can offer the methodology of precise, objective, and systematic cancer classification. Moreover, since accurate classification of cancer is very important issue for treatment of cancer, it is desirable to make a decision by combining the results of various basis classifiers rather than by deciding the result with only one classifier. Generally combining classifiers gives high performance and high confidence. In spite of many advantages of ensemble classifiers, ensemble with mutually error-correlated classifiers has a limit in the performance. In this paper, we propose the ensemble of neural network classifiers learned from negatively correlated features to precisely classify cancer, and systematically evaluate the performances of the proposed method using three benchmark datasets. Experimental results show that the ensemble classifier with negatively correlated features produces the best recognition rate on the three benchmark datasets.
机译:虽然在临床实践中诊断癌症的几种常规技术可能是不完全或误导的,但具有基因表达谱的分子水平诊断可以提供精确,目标和系统性癌症分类的方法。此外,由于癌症的准确分类是治疗癌症的非常重要的问题,因此期望通过组合各种基础分类器的结果而不是通过仅使用一个分类器决定结果来做出决定。通常,组合分类器具有高性能和高信心。尽管集合分类器的许多优点,具有相互错误相关的分类器的集合在性能下有限制。在本文中,我们提出了神经网络分类器的集合,从负相关的特征中学到精确分类癌症,并系统地评估使用三个基准数据集的提出方法的性能。实验结果表明,具有负相关的功能的集合分类器在三个基准数据集中产生最佳识别率。

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