HYBRID WOUND DEVICES FOR SPATIOTEMPORALLY CONTROLLED RELEASE KINETICS

摘要

This research presents hybrid full thickness wound devices for improved wound healing process. Firstly, a 3D wound bed surface is extracted using imaging study. Then, a 3D lofting process from our previous work [1] is applied to discretize the device geometry into a number of healing regions based on linear wound margin healing fashion. Next, CAD models are developed and inputted into a multi-nozzle rapid prototyping system for biofabrication purposes. Hybrid devices are finally fabricated with varying concentration of biological modifiers and biomaterials to control the release kinetics spatiotemporally. The proposed methodology is implemented and an illustrative hybrid wound device is presented.