Mn-Zn Ferrite and Photosensitizer Co-loaded Cancer Theragnostic Agent for Magnetic Resonance Imaging and Photodynamic Therapy

摘要

In this report, a multifunctional cancer diagnostic system based on manganese-zinc ferrite (MZF) and chlorin e6 (Ce6) co-loaded nanoclusters were demonstrated for magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The results showed that the MZF and Ce6 co-loaded nanoclusters with particle size around 100 nm exhibited almost non-toxic to the KB cells under 200 μg Fe/ml and had better T2 relaxivity and darker T2-weighted MR images comparing to the commercial Resovist®. Thus, this system may have highly potential diagnostic abilities for in nasopharyngeal cancer or other cancers.