Cytocompatible poly-lactic-co-glycolic acid: Carbon nanofiber composite analysis for cardiovascular applications

摘要

The objective of the present research was to determine cardiomyocyte function on poly lactic-co-glycolic acid (50∶50 wt. % (PLA∶PGA); PLGA) with greater amounts of carbon nanofibers (CNFs) for myocardial tissue engineering applications. The addition of CNFs could increase conductivity and strength of pure PLGA. For this reason, different PLGA∶CNF ratios (100∶0, 75∶25, 50∶50, 25∶75, 0∶100 wt.%) were created and conductivity and cytocompatibility properties with human cardiomyocytes were determined. Results showed that PLGA∶CNF materials were conductive and that conductivity increased as greater amounts of CNFs were added to PLGA, from 0 S.m−1 for 100∶0 (pure PLGA) to 5.5×10−3 S.m−1 for 0∶100 (pure CNFs). Furthermore, results indicated that cardiomyocyte density up to 5 days, increased with greater amounts of CNFs in PLGA (up to 25∶75, PLGA∶CNFs). Thus, this study provided an alternative conductive scaffold using nanotechnology which should be further explored for cardiovascular applications.