The objective of this study was to evaluate the value of the extra time and cost required for different levels of data standards implementation and the likelihood of researchers to comply with these different levels. Since we believe that the cost and time necessary for data standard implementation can change over time, System Dynamics (SD) analysis was used to investigate how these variables interact and influence the data standard adoption by clinical researchers. Three levels of data standards implementation were defined trough a focus group with four clinical research investigators. Brazilian and American investigators responded to an online questionnaire with possible scenarios regarding options for standards implementation, and choose one of two options presented in each scenario. A random effects ordered probit model was used to estimate the effect of cost and time on investigators willingness to adehere to data standards.A preference for low cost and fast implementation time standards was observed, and investigators were more likely to incur costs than to accept a time delay in project start-up. The SD analysis indicated that initially there are extra time and cost necessary to clinical studycstandardilation,however, over time a there is a decrease in cost and time.
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