SIMULATIONS IN GENOME MAPPING

摘要

Genome mapping is a major part of genome projects and precondition for most genomic applications. Any organism with economical or ecological importance is (or will be) a target for genome mapping. The aim of this workshop is to demonstrate simulation and optimization methods employed in our software packages for genome mapping, including construction of genetic maps, mapping quantitative trait loci (QTL) and building physical maps. The presented paper describes the process of simulations in these packages in three aspects: (ⅰ) for generation artificial datasets with intended properties in order to compare different analytical approaches, (ⅱ) for analysis of solution quality, and (ⅲ) as a central component in Evolutionary Optimization algorithms that mimic natural population-biology processes.