In vivo animal experimental research of magnetic nanoparticles influence on pulse wave

摘要

In vivo animal experimental research is performed to study the influence of magnetic nanoparticles on the pulse wave. An interventional pulse wave transducer is connected to the rabbit's blood circulation through the ingenious two-end carotid intubations, so that the pulse wave with low noise could be acquired. The data obtained before and after the injection of the magnetic nanoparticles, which have the diameter of 20 nm, is processed and compared in both time and frequency domain. It is found that after injection, pulse wave height is about 10 mmHg higher, and its interval is about 4.55% longer. While the fluctuation of respiration is much more gently, the acuity of pulse wave fluctuation increases. It is likely to say that injection has elevated the blood pressure and brought down the excitation of the rabbits. According to the relationship between the blood pressure and the blood viscosity of human body, the injection of nanoparticles has increased the blood viscosity of the rabbit. The results are very instructive for the study of in vivo transport of magnetic nanoparticles, which is the base of targeted drug delivery, hyperthermia and embolism therapy using nanoparticles.