A NOVEL SCANNING METHOD TO MEASURE SHEAR RATE AROUND A THROMBUS USING MICRO PARTICLE IMAGE VELOCIMETRY

摘要

The ability of platelets to adhere and aggregate to form a stable thrombus plays a key role in the normal haemostatic process at sites of vascular injury. However, thrombus formation plays a sinister role in arterial diseases leading to heart attacks or strokes.Platelet activation depends on both chemical stimuli and hemodynamic forces. Irregular arterial geometries such as bifurcations, curved or stenotic vessels affect the hemodynamic forces experienced by platelets and may lead to thrombus formation.