INJURY DRIVEN BIOLOGICAL MODEL OF RESTENOTIC LESION DEVELOPMENT PREDICTS THE EFFECTS OF STENT GEOMETRY ON RESTENOSIS

摘要

One of the most significant limitations of percutaneous coronary intervention using stents is the growth of tissue within the stent, leading to re-occlusion of the target vessel. There is a wide range of stents available, and stent designs differ in their efficacy [1]. Stent parameters such as stent length, strut configuration, diameter and expansion method have been shown to influence the amount of restenosis provoked [2]. Despite many generations of coronary stents -and the advent of drug elution - up to 10% of percutaneous coronary interventions require revision, climbing to 50% in some high risk lesions [3].