Synthesis, Characterization and Cell-uptake of Porphyrin-capped Gold Nanoparticle

摘要

In order to improve the cell uptake effect of porphyrins and their derivatives,gold nanoparticle was chosen as carrier.We report our preliminary result on synthesis and characterization of thiol tailored porphyrin and porphyrin capped gold nanoparticle,their interaction with cell by TEM,UV-Visible spectra,fluorescent spectra and confocal microscopy.Our results show that porphyrins modified gold nanoparticles have low cytotoxicity and acceptable fluorescence emission,and reliable cell uptake ability.Gold nanoparticle is an ideal carrier to delivery the porphyrin molecule into cell which make porphyrin modified gold nanoparticles as a potential agent in PDT and molecular image.