99mTc-EDDA/HYNIC-TOC in gastroenteropancreatic neuroendocrine tumors

摘要

Somatostatin receptors have been identified on most endocrine tumors, including carcinoidtumors, which generally express a high density of the receptors. The scintigraphy allows thelocalization and staging of tumors, and has benefit in identifying small primary tumors and detectingmetastases. The high cost of 111In Octreotide turns difficult the access to this modality of diagnosis.Theaim of this work was to analize the ability in detecting gastroenteropancreatic neuroendocrine tumorsby somatostatin receptors with 99mTc-EDDA/Hynic-Toc scintigraphy. Twenty-four patients werestudied to diagnosis and to determine the staging of disease by somatostatin receptor scintigraphywith99mTc- EDDA-Hynic-Toc. Scintigraphy was performed at 3 h (planar and tomographic images) and24 h (planar images) after injection of 740 MBq of 99mTc- EDDA-Hynic-Toc.We compare the 99mTc-EDDA-Hynic-Toc scintigraphy with the findings of CT, MRI, ultrasonography, and/or selectiveangiography. This study revealed a higher sensitivity of 99mTc-EDDA-Hynic-Toc as a diagnosticprocedure in gastroenteropancreatic neuroendocrine tumors.