A new mathematical formulation for scheduling multi-purpose continuous processes is presented, based on an event-driven representation of time, and resulting into a mixed-integer linear programming (MILP) model. The formulation is applicable to arbitrary process structures, variable unit processing rates, sequence-dependent changeovers, and flexible storage requirements. A medium-to-large scale manufacturing process is examined to illustrate the applicability and efficiency of the method. The formulation is shown to compare favorably with existing continuous-time models.
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