INTRATHECAL APPLICATION OF LIPOSOME-ENTRAPPED FASUDIL FOR ACUTE STROKE IN A RAT MODEL

机译：脂质体包裹的急性卒中模型在大鼠模型中的鞘内应用

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A liposomal drug delivery system for intrathecal applications of an antivasospastic agent (Fasudil) was studied. Improvements in the therapeutic efficacy of encapsulated Fasudil, were demonstrated against cerebral ischemia and cerebral vasospasm in animal models. This new approach showed significant potential for liposomal antivasospastic agents for acute stroke.

机译：研究了用于鞘内应用抗血管痉挛药（法舒地尔）的脂质体药物递送系统。在动物模型中证明了包封的法舒地尔的治疗功效的改善对脑缺血和脑血管痉挛。这种新方法显示了脂质体抗血管痉挛药物在急性中风方面的巨大潜力。

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《International symposium on controlled release of bioactive materials;Consumer diversified products conference 》|2001年|p.532-533|共2页
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T. Ishida; Y. Takanashi; M.J. Kirchmeier; T.M. Allen; J.H. Zhang;
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中图分类基础医学 ;
关键词
liposomes; controlled release; brain-targeted delivery; encapsulation; drug delivery system;

机译：脂质体控释;以大脑为目标的分娩;封装药物输送系统;

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专利

1. Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil. [J] . Ishida T, Takanashi Y, Kiwada H Biological & pharmaceutical bulletin . 2006 ,第3期

机译：具有脂质体的安全有效的药物输送系统，用于鞘内应用抗血管痉挛药物法舒地尔。
2. A spatiotemporal theory for MRI T-2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: Application and validation in a rat acute stroke model [J] . Knight Michael J., McGarry Bryony L., Rogers Harriet J., Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2016 ,第7期

机译：急性缺血时脑中MRI T-2弛豫时间和表观扩散系数的时空理论：在大鼠急性中风模型中的应用和验证
3. The relationship of intrathecal immunoglobulin levels with clinic symptoms and prognosis for acute phase ischemic stroke patients [J] . Asl? Bolay?r, Hesna Bekta?, Zeynep Iss?, Cumhuriyet Medical Journal . 2014 ,第4期

机译：急性期缺血性脑卒中患者鞘内免疫球蛋白水平与临床症状和预后的关系
4. Application of Evoked Potential in Acute Stroke in Rats [C] . Yang Shao Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：诱发电位在大鼠急性中风中的应用
5. The antinociceptive effects of intrathecally administered neuropeptide Y (NPY) in an animal model of acute pain. [D] . Mahinda, Tania Biliha. 2003

机译：鞘内注射神经肽Y（NPY）在急性疼痛动物模型中的抗伤害感受作用。
6. A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: Application and validation in a rat acute stroke model [O] . Michael J Knight, Bryony L McGarry, Harriet J Rogers, 2016

机译：急性缺血时脑中MRI T2弛豫时间和表观扩散系数的时空理论：在大鼠急性中风模型中的应用和验证
7. Safe and Efficient Drug Delivery System with Liposomes for Intrathecal Application of an Antivasospastic Drug, Fasudil [O] . Tatsuhiro Ishida, Yoshihiro Takanashi, Hiroshi Kiwada 2006

机译：具有脂质体的安全有效的药物递送系统，用于鞘内复杂药物，Fasudil

INTRATHECAL APPLICATION OF LIPOSOME-ENTRAPPED FASUDIL FOR ACUTE STROKE IN A RAT MODEL

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