INFLUENCE OF HPMC PARTICLE PROPERTIES AND ETHYLCELLULOSE COATING ON THE RELEASE BEHAVIOR OF ASPIRIN FROM MATRIX TABLETS

机译：HPMC颗粒特性和乙基纤维素涂层对矩阵片中阿司匹林释放行为的影响

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The quantitative effects of hydroxypropyl methylcellulose (HPMC) particle properties on the release behavior of aspirin from a swellable matrix tablet system were investigated. The drug release kinetics were found to be dependent on the summative influence of polymer content in the tablet core, quantity of ethylcellulose coating and the concentration of soluble modifier in the coating formulation on drug release kinetics.

机译：研究了羟丙基甲基纤维素（HPMC）颗粒性质对阿司匹林从可膨胀基质片剂系统释放行为的定量影响。发现药物释放动力学取决于片剂核中聚合物含量，乙基纤维素包衣的量以及包衣制剂中可溶性调节剂的浓度对药物释放动力学的累加影响。

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《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.776-777|共2页
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作者
P.W.S. Heng; X.M. Li; L.W. Chan; M.G. Easterbrook;
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中图分类基础医学;
关键词
matrices; coating; cellulose derivatives; release kinetics;

机译：矩阵涂层;纤维素衍生物释放动力学;

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专利

1. Influence of ionic strength and HPMC viscosity grade on drug release and swelling behavior of HPMC matrix tablets [J] . Krese Ana, Kovacic Natasa Nagelj, Kapele Tomaz, Journal of Applied Polymer Science . 2016,第25a26期

机译：离子强度和HPMC粘度等级对HPMC基质片释药和溶胀行为的影响
2. Preparation of Sustained-Release Matrix Tablets of Aspirin with Ethylcellulose, Eudragit RS100 and Eudragit S100 and Studying the Release Profiles and their Sensitivity to Tablet Hardness [J] . Guilani TB, Mortazavi SA, Tabandeh H Iranian Journal of Pharmaceutical Research . 2010,第4期

机译：乙基纤维素，Eudragit RS100和Eudragit S100制成的阿司匹林缓释基质片剂的制备及其药物释放特性及其对片剂硬度的敏感性研究
3. Influence of sodium dodecyl sulfate on swelling, erosion and release behavior of HPMC matrix tablets containing a poorly water-soluble drug. [J] . Zeng A, Yuan B, Fu Q, Pharmaceutical development and technology . 2009,第5期

机译：十二烷基硫酸钠对水溶性差的HPMC基质片剂的溶胀，腐蚀和释放行为的影响。
4. The influence of Solubility of Additives and Dose on the Release from HPMC matrix tablets [C] . Farhad Tajarobi, Susanna Abrahmsén-Alami, Anders S. Carlsson, Annual meeting exposition of the Controlled Release Society . 2009

机译：添加剂的溶解度和剂量对HPMC基质片剂释放的影响
5. Zero-order release of aspirin and theophylline from novel synthesized methylcellulose succinate and hypromellose glutarate matrix tablets. [D] . Vaghasia, Brijeshkumar V. 2010

机译：从新型合成琥珀酸甲基纤维素和谷氨酸羟丙甲纤维素基质片剂中零级释放阿司匹林和茶碱。
6. Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release [O] . Anna Nardi-Ricart, Isaac Nofrerias-Roig, Marc Suñé-Pou, 2020

机译：甲醛酮持续释放亲水基质片剂的制剂与沉体图的应用：Tolcapone粒径对持续释放的影响
7. Influence of Compression Force on Consolidation Behavior and Drug Release Property of Wax Matrix Tablets. [O] . Ryuzo ISHINO, Hiroyuki YOSHINO, Yoshiyuki HIRAKAWA, 1991

机译：压缩力对蜡基质片的固结行为和药物释放性能的影响。

INFLUENCE OF HPMC PARTICLE PROPERTIES AND ETHYLCELLULOSE COATING ON THE RELEASE BEHAVIOR OF ASPIRIN FROM MATRIX TABLETS

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