CHITOSAN AND CHITOSAN-PEO SEMI-INTERPENETRATING NETWORKS AS DRUG DELIVERY SYSTEM FOR ORAL ADMINISTRATION AND BIOMATERIALS COATING

摘要

Chitosan crosslinked networks and chitosan-PEO semi-interpenetrating networks were synthesized as oral drug delivery system. Both systems were loaded with aspirin, theophylline and caffeine and characterized through swelling and release kinetics studies at pH=1.2 and pH=7.2. Systems loaded with aspirin were also sterilized using ethylene oxyde (EtO) and Sterrad-100~(~R) and studied as coatings of cardiac stents for local drug targeting.