CHARACTERISATION OF THE BRONCHIAL EPITHELIAL CELL LINE 16HBE14O- AS AN IN VITRO MODEL FOR DRUG ABSORPTION: EXPRESSION OF P-GLYCOPROTEIN, LRP-56 AND CAVEOLIN-1

摘要

The bronchial epithelial cell line 16HBE14o- was investigated as a possible in vitro model for transepithelial absorption in the upper lungs with special attention on active transport systems, relevant to drug transport, like P-glycoprotein (P-gp), lung resistance protein (LRP-56) and caveolin-1.