The solubilisation of some hydrophobic drugs using tapered statistical block copolymers

摘要

The ability of poly(oxyalkylene) (POA) block copolymers to form micelles at low concentration has led to these structures being studied for their potential as carriers for novel and existing drugs~1. The amphiphilic nature of POA copolymers also allows them to circulate in the body for extended periods as a result of their avoidance of the reticuloendothelial system (RES)~2. POA copolymers also have potential in the solubilisation of hydrophobic drug substances and have been investigated for use in drug delivery forms~3. However, traditional diblock and triblock POA copolymer micelles have been found to be relatively poor solubilisers, a characteristic which has been attributed to the location of solubilised drugs at the hydrophobic/hydrophilic interface~4, and to their small size.