In vitro assessment and clinical performance of a new transdermal electrotransport system for patient-controlled delivery of the analgesic fentanyl

摘要

Electrotransport (ET) is the use of an electrical potential to aid movement of molecules through biological tissues such as skin. Drug delivery by transdermal ET can offer a painless and noninvasive alternative to traditional methods of parenteral drug delivery. Using E-TRANS~TM technology, ALZA has developed ET systems that are small enough to be worn unobtrusively with few restrictions on patient activity, and that provide preprogrammed, sensor-actuated, or patient-controlled drug delivery.