Interactions between non-ionic surfactant vesicles and peyer's patches - a clsm study

摘要

The majority of infectious diseases is encountered through the large area of the body's mucosal surfaces as e. g. gastro-intestinal tract, respiratory tract and uro-genital tract. These surfaces are protected by their own secretory immune system which cannot be activated efficiently by the parenteral route. However, presently most vaccines for protection against both superficial and systemic pathogens are administered parenterally in order to avoid antigen degradation by gastric acidity and proteolytic enzymes in the gut. Oral vaccination. However, activates the gastro-intestinal system and also other mucosal sites and offers a number of further advantages over the parenteral route, including ease and convenience of administration, increased patient compliance, reduced costs and minimal side effects and thus a greater possibility of frequent boosting.