Epr study of loading capacity and location of spinlabeled lipophilic substance in different sln

摘要

Solid lipid nanoparticles (SLN) are an attractive alternative drug carrier system to polymeric nanoparticles, emulsions and liposomes. These systems represent aqueous colloidal dispersions of biodegradable lipids which are solid at room temperature. Due to rigidity of SLN it is supposed that the mobility of incorporated drug is reduced and therefore drug leakage from the carrier is prevented. Drugs may be adsorbed on particle surface, entrapped or dissolved in solid lipid core or in the outer layer of SLN composed of phospholipid and steric stabilisers. The way of incorporation depends strongly on the physicochemical charateristics of drug and SLN. Investigations about drug incorporation give an important information for the degisn and evaluation of a potential drug carrier system.